IN THE SPOTLIGHT MTOR Mutations in the Crosshairs of Targeted Therapy
نویسندگان
چکیده
Authors’ Affi liation: Oncology Research Unit, Pfi zer Worldwide Research and Development, San Diego, California Corresponding Author: Robert T. Abraham, Oncology Research Unit, Pfi zer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121. Phone: 858-526-4772; E-mail: Robert.Abraham@ pfi zer.com doi: 10.1158/2159-8290.CD-14-0332 ©2014 American Association for Cancer Research. Summary: The identifi cation of genetic lesions that affect tumor sensitivity to targeted therapies is a major objective of precision medicine. Two reports in this issue combine tumor genome analyses with functional characterization to uncover activating mutations in MTOR that confer sensitivity to a clinically used mTOR inhibitor. Cancer Discov; 4(5); 513–5. ©2014 AACR.
منابع مشابه
MTOR mutations in the crosshairs of targeted therapy.
The identification of genetic lesions that affect tumor sensitivity to targeted therapies is a major objective of precision medicine. Two reports in this issue combine tumor genome analyses with functional characterization to uncover activating mutations in MTOR that confer sensitivity to a clinically used mTOR inhibitor.
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